The overarching objective of the BIOIMAGE-NMD project is to deliver combined structural and molecular imaging biomarkers with proven utility for the detection of therapeutic effects in patients with rare neuromuscular diseases (NMD).
The project will have three specific objectives:
1. To develop a new generation of muscle diffusion Magnetic Resonance Imaging (MRI). This diffusion imaging technology will be used to augment a state of the art simultaneous MRI / Magnetic Resonance Spectroscopic Imaging (MRSI) protocol for quantitative muscle imaging.
2. To provide a proof of principle in Duchenne Muscular Dystrophy (DMD) that simultaneous MRI/MRSI can be used as a biomarker to monitor therapeutic efficacy in clinical trials in neuromuscular diseases.
3. To develop a novel simultaneous Positron Emission Tomography (PET)/MRI technology to advance innovative drug development programmes for personalised medicines based on Antisense Oligonucleotide technology.
Volker Straub, Insitute for Genetic Medicine, Newcastle University, UK